Grey's Anatomy is an American medical drama television series that premiered on the American Broadcasting Company as a mid-season replacement on March 27, 2005. The series has aired ten seasons, and focuses on the fictional lives of surgical interns and residents as they gradually evolve into seasoned doctors, while trying to maintain personal lives. The title is a play on the name Gray's Anatomy, an English-language human anatomy textbook originally written by Henry Gray. Earlier editions were called Anatomy: Descriptive and Surgical, but the book's name is commonly shortened to, and later editions are titled, Gray's Anatomy. The show's premise originated with Shonda Rhimes, who serves as an executive producer, along with Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding, and Allan Heinberg. The series was created to be racially diverse, utilizing a color-blind casting technique. While the show is set in Seattle, it is primarily filmed in Los Angeles, California.
The series' protagonist is Dr. Meredith Grey, who originally is accepted into the residency program at the fictional Seattle Grace Hospital. Meredith is assigned to work under Dr. Miranda Bailey, along with Dr. Cristina Yang, Dr. George O'Malley, Dr. Izzie Stevens, and Dr. Alex Karev. Following O'Malley's death and Stevens' departure, the hospital's merger with Mercy West brings in Dr. Jackson Avery and Dr. April Kepner, in the sixth season.