A reality television show on WEtv, called A Standup Mother, related Pescatelli's life as a mother, wife, and comedian.
In 2000, she and Patty Rosborough won Ladies of Laughter, a multi-national competition for stand-up comics, hosted in the Northeastern United States.
In 2010, Pescatelli won Comedy Central's Standup Showdown. In 2004, she was a finalist on the second and third seasons of Last Comic Standing. She has performed on The Tonight Show with Jay Leno, The Talk, Rocco's Dinner Party, Comedy Central Presents, The World Stands Up, The Bonnie Hunt Show, Last Call with Carson Daly, Dennis Miller, and Comics Unleashed.
Tammy is a regular guest on The Bob & Tom Show in Indianapolis, and is a fixture on the comedy channels of Sirius XM Radio. On January 22, 2010, she was a guest on Opie and Anthony, an XM Satellite Radio talk show. She also appeared as a guest on Ron & Fez on SiriusXM Raw Dog Comedy on Channel 99
Her film appearances include minor roles in Made in Brooklyn, Single: A Documentary Film, and Everybody Wants to Be Italian.
She has performed for the United Service Organizations on at least six occasions.
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